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- Vulnerable plaque has high concentration of macrophages, neovascularization, large necrotic core, low concentration of collagen
- Class IA drugs reduce rate of rise of action potential upstroke (Vmax) and prolong action potential duration
- s/p cardiac transplant, on tacrolimus (metabolized by P450 enzyme system) & voriconazole (P450 inhibitor), stopping voriconazole allows P450 metabolize tacrolimus. Low tacrolimus causes allograft rejection, fall in EF
- Rubella syndrome includes PDA or pulmonic valvular stenosis
- Likelihood of developing dilated cardiomyopathy correlates with the amount of alcohol consumed over lifetime
- Fever, vegetation, bilateral rales - urgent valve replacement
- Multiple risk factors for CAD, lower lipids with high intensity statin eg. 40 to 80 mg of atorvastatin or 20 to 40 mg of rosuvastatin
- Complete d TGA presents with cyanosis
- Leg pain, cool, mottled, decreased pinprick sensation above toes, decreased power, pulses not palpable, venous Doppler appreciated - immediately threatened, Urgent revascularization (if sensory loss to toes, no weakness - marginally threatened, do CT angio/contrast angio)
- Cutoff for rise in creatinine before stopping ACE inhibitor is 35% increase